-Bullous Pemphigoid-
-comes from interaction of the autoantibody with bullous pemphigoid antigen on the surface of the keratinocytes
-Bullous lesion comes from multiple molecules released from mast cells and eosinophils
-prefers the axillae, medial aspects of the thighs, groin, abdomen, arms and legs (flexor surfaces)
-Diagnosis is made by skin biopsy
-Treatment-Prednisone 50-100 mg daily until clear combined with azathoprine 150 mg daily
-Tetracycline have been effective in some cases
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